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Murch SJ, Simmons CB, Saxena PK. Melatonin in feverfew and other medicinal plants. Lancet 1997;350:1598-9. View abstract.

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Ondrizek RR, Chan PJ, Patton WC, King A. Inhibition of human sperm motility by specific herbs used in alternative medicine. J Assist Reprod Genet 1999;16:87-91. View abstract.

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Ruschitzka F, Meier PJ, Turina M, et al. Acute heart transplant rejection due to Saint John's wort. Lancet 2000;355:548-9. View abstract.

Saito YA, Rey E, Almazar-Elder AE, et al. A randomized, double-blind, placebo-controlled trial of St. John's wort for treating irritable bowel syndrome. Am J Gastroenterol 2010;105:170-7. View abstract.

Samadi S, Khadivzadeh T, Emami A, et al. The effect of Hypericum perforatum on the wound healing and scar of cesarean. J Altern Complement Med 2010;16:113-7. View abstract.

Schempp C, Pelz K, Wittmer A, et al. Antibacterial activity of hyperforin from St. John's wort, against multiresistant Stapylococcus aureus and gram-positive bacteria. Lancet 1999;353:2129. View abstract.

Schempp CM, Kirkin V, Simon-Haarhaus B, et al. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Oncogene 2002;21:1242-50.. View abstract.

Schempp CM, Ludtke R, Winghofer B, Simon JC. Effect of topical application of hypericum perforatum extract on skin sensitivity to solar simulated radiation. Photodermatol Photoimmunol Photomed 2000;16:125-8. View abstract.

Schempp CM, Muller K, Winghofer B, et al. Single-dose and steady-state administration of Hypericum perfotatum extract (St. John's wort) does not influence skin sensitivity to UV radiation, visible light, and solar-stimulated radiation. Arch Dermatol 2001;137:512-3. View abstract.

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Schempp CM, Winghofer B, Ludtke R, et al. Topical application of St. John's wort (Hypericum perforatum L.) and its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells. Br J Dermatol 2000;142:979-84. View abstract.

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Schrader E. Equivalence of St. John's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression. Int Clin Psychopharmacol 2000;15:61-8. View abstract.

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Schulz V. Incidence and clinical relevance of the interactions and side effects of Hypericum preparations. Phytomedicine 2001;8:152-60. View abstract.

Schwarz UI, Buschel B, Kirch W. Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception. Br J Clin Pharmacol 2003;55:112-3. View abstract.

Shan MD, Hu LH, Chen ZL. Three new hyperforin Analogues from Hypericum perforatum. J Nat Prod 2001;664:127-30. View abstract.

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Shelton RC. St John's Wort for the treatment of depression. Lancet Neurol 2002;1:275. View abstract.

Shimizu K, Nakamura M, Isse K, Nathan PJ. First-episode psychosis after taking an extract of Hypericum perforatum (St John's Wort). Hum Psychopharmacol 2004;19:275-6. View abstract.

Siepmann M, Krause S, Joraschky P, et al. The effects of St John's wort extract on heart rate variability, cognitive function and quantitative EEG: a comparison with amitriptyline and placebo in healthy men. Br J Clin Pharmacol 2002;54:277-82. View abstract.

Sindrup SH, Madsen C, Bach FW, et al. St. John's wort has no effect on pain in polyneuropathy. Pain 2000;91:361-5. View abstract.

Singer A, Wonnemann M, Muller WE. Hyperforin, a major antidepressant constituent of St. John's wort, inhibits serotonin uptake by elevating free intracellular Na+1. J Pharmacol Exp Ther 1999;290:1363-8.. View abstract.

Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. View abstract.

Jensen AG, Hansen SH, Nielsen EO. Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life Sci 2001;68:1593-605. View abstract.

Pajonk, F., Scholber, J., and Fiebich, B. Hypericin-an inhibitor of proteasome function. Cancer Chemother.Pharmacol 2005;55(5):439-446. View abstract.

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Papakostas, G. I., Crawford, C. M., Scalia, M. J., and Fava, M. Timing of clinical improvement and symptom resolution in the treatment of major depressive disorder. A replication of findings with the use of a double-blind, placebo-controlled trial of Hypericum perforatum versus fluoxetine. Neuropsychobiology 2007;56(2-3):132-137. View abstract.

Pietta, P., Gardana, C., and Pietta, A. Comparative evaluation of St. John's wort from different Italian regions. Farmaco 2001;56(5-7):491-496. View abstract.

Rahimi, R., Nikfar, S., and Abdollahi, M. Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: a meta-analysis. Prog.Neuropsychopharmacol.Biol.Psychiatry 2-1-2009;33(1):118-127. View abstract.

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Sardella, A., Lodi, G., Demarosi, F., Tarozzi, M., Canegallo, L., and Carrassi, A. Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study. J.Oral Pathol.Med. 2008;37(7):395-401. View abstract.

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Schempp, C. M., Winghofer, B., Muller, K., Schulte-Monting, J., Mannel, M., Schopf, E., and Simon, J. C. Effect of oral administration of Hypericum perforatum extract (St. John's Wort) on skin erythema and pigmentation induced by UVB, UVA, visible light and solar simulated radiation. Phytother Res 2003;17(2):141-146. View abstract.

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Fogle RH, Murphy PA, Westhoff CL, Stanczyk FZ. Does St. John's wort interfere with the antiandrogenic effect of oral contraceptive pills? Contraception 2006;74:245-8. View abstract.

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Goey AK, Meijerman I, Rosing H, et al. The effect of St John's wort on the pharmacokinetics of docetaxel. Clin Pharmacokinet 2014;53(1):103-10. View abstract.

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Gulick RM, McAuliffe V, Holden-Wiltse J, et al. Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258. Ann Intern Med 1999;130:510-4. View abstract.

Gurley BJ, Barone GW. Herb-drug interaction involving St. John's wort and cyclosporine. AAPS Ann Mtg & Expo Indianapolis, IN:2000;Oct 29- Nov 2: presentation #3443.

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Hammerness P, Basch E, Ulbricht C, et al. St. John's wort: a systematic review of adverse effects and drug interactions for the consultation psychiatrist. Psychosomatics 2003;44:271-82. View abstract.

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Holme SA, Roberts DL. Erythroderma associated with St John's wort. Br J Dermatol 2000;143:1127-8. View abstract.

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Hussain MD, Teixeira MG. Saint John's wort and analgesia: effect of Saint John's wort on morphine induced analgesia. AAPS Ann Mtg & Expo Indianapolis, IN:2000;Oct 29- Nov 2:presentation #3453.

Hypericum Depression Trial Study Group. Effect of Hypericum perforatum (St. John's wort) in major depressive disorder: a randomized controlled trial. JAMA 2002;287:1807-14. View abstract.

Irefin S, Sprung J. A possible cause of cardiovascular collapse during anesthesia: long-term use of St. John's Wort. J Clin Anesth 2000;12:498-9. View abstract.

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Al-Akoum, M., Maunsell, E., Verreault, R., Provencher, L., Otis, H., and Dodin, S. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause. 2009;16(2):307-314. View abstract.

Andreescu, C., Mulsant, B. H., and Emanuel, J. E. Complementary and alternative medicine in the treatment of bipolar disorder--a review of the evidence. J.Affect.Disord. 2008;110(1-2):16-26. View abstract.

Bancirova, M. and Lasovsky, J. The photodynamic effect: the comparison of chemiexcitation by luminol and phthalhydrazide. Luminescence. 2011;26(6):410-415. View abstract.

Barbenel, D. M., Yusufi, B., O'Shea, D., and Bench, C. J. Mania in a patient receiving testosterone replacement postorchidectomy taking St John's wort and sertraline. J Psychopharmacol 2000;14(1):84-86. View abstract.

Berlanda, J., Kiesslich, T., Engelhardt, V., Krammer, B., and Plaetzer, K. Comparative in vitro study on the characteristics of different photosensitizers employed in PDT. J.Photochem.Photobiol.B 9-2-2010;100(3):173-180. View abstract.

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Bhattacharya, S. K., Chakrabarti, A., and Chatterjee, S. S. Activity profiles of two hyperforin-containing hypericum extracts in behavioral models. Pharmacopsychiatry 1998;31 Suppl 1:22-29. View abstract.

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Bladt, S. and Wagner, H. Inhibition of MAO by fractions and constituents of hypericum extract. J Geriatr.Psychiatry Neurol. 1994;7 Suppl 1:S57-S59. View abstract.

Bombardelli E and Morazzoni P. Hypericum perforatum. Fitoterapia 1995;66(1):43-68.

Brattstrom, A. Long-term effects of St. John's wort (Hypericum perforatum) treatment: a 1-year safety study in mild to moderate depression. Phytomedicine. 2009;16(4):277-283. View abstract.

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Canning, S., Waterman, M., Orsi, N., Ayres, J., Simpson, N., and Dye, L. The efficacy of Hypericum perforatum (St John's wort) for the treatment of premenstrual syndrome: a randomized, double-blind, placebo-controlled trial. CNS.Drugs 2010;24(3):207-225. View abstract.

Cappuzzo, K. A. Herbal product use in a patient with polypharmacy. Consult Pharm. 2006;21(11):911-915. View abstract.

Carpenter, S. and Kraus, G. A. Photosensitization is required for inactivation of equine infectious anemia virus by hypericin. Photochem.Photobiol. 1991;53(2):169-174. View abstract.

Chatterjee SS, Bhattacharya SK, Singer A, and et al. Hyperforin inhibits synaptosomal uptake of neurotransmitters in vitro and shows antidepressant activity in vivo. Pharmazie 1998;53(3):9.

Clewell, A., Barnes, M., Endres, J. R., Ahmed, M., and Ghambeer, D. K. Efficacy and tolerability assessment of a topical formulation containing copper sulfate and hypericum perforatum on patients with herpes skin lesions: a comparative, randomized controlled trial. J.Drugs Dermatol. 2012;11(2):209-215. View abstract.

Cohen, P. A., Hudson, J. B., and Towers, G. H. Antiviral activities of anthraquinones, bianthrones and hypericin derivatives from lichens. Experientia 2-15-1996;52(3):180-183. View abstract.

Cott, J. M. In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract. Pharmacopsychiatry 1997;30 Suppl 2:108-112. View abstract.

Couldwell, W. T., Gopalakrishna, R., Hinton, D. R., He, S., Weiss, M. H., Law, R. E., Apuzzo, M. L., and Law, R. E. Hypericin: a potential antiglioma therapy. Neurosurgery 1994;35(4):705-710. View abstract.

Couldwell, W. T., Surnock, A. A., Tobia, A. J., Cabana, B. E., Stillerman, C. B., Forsyth, P. A., Appley, A. J., Spence, A. M., Hinton, D. R., and Chen, T. C. A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. Cancer 11-1-2011;117(21):4905-4915. View abstract.

Cui, Y., Ang, C. Y., Beger, R. D., Heinze, T. M., Hu, L., and Leakey, J. In vitro metabolism of hyperforin in rat liver microsomal systems. Drug Metab Dispos. 2004;32(1):28-34. View abstract.

Degar, S., Prince, A. M., Pascual, D., Lavie, G., Levin, B., Mazur, Y., Lavie, D., Ehrlich, L. S., Carter, C., and Meruelo, D. Inactivation of the human immunodeficiency virus by hypericin: evidence for photochemical alterations of p24 and a block in uncoating. AIDS Research and Human Retroviruses 1992;8(11):1929-1936. View abstract.

Demiroglu, Y. Z., Yeter, T. T., Boga, C., Ozdogu, H., Kizilkilic, E., Bal, N., Tuncer, I., and Arslan, H. Bone marrow necrosis: a rare complication of herbal treatment with Hypericum perforatum (St. John's wort). Acta Medica.(Hradec.Kralove) 2005;48(2):91-94. View abstract.

Demisch L, Holzl J, Gollnik B, and et al. Identification of selective MAO-type-A inhibitors in Hypericum perforatum L. (Hyperforat). Pharmacopsychiat. 1989;22:194.

Di Carlo, G., Nuzzo, I., Capasso, R., Sanges, M. R., Galdiero, E., Capasso, F., and Carratelli, C. R. Modulation of apoptosis in mice treated with Echinacea and St. John's wort. Pharmacol Res 2003;48(3):273-277. View abstract.

Di, Matteo, V, Di Giovanni, G., Di Mascio, M., and Esposito, E. Effect of acute administration of hypericum perforatum-CO2 extract on dopamine and serotonin release in the rat central nervous system. Pharmacopsychiatry 2000;33(1):14-18. View abstract.

Dona, M., Dell'Aica, I., Pezzato, E., Sartor, L., Calabrese, F., Della, Barbera M., Donella-Deana, A., Appendino, G., Borsarini, A., Caniato, R., and Garbisa, S. Hyperforin inhibits cancer invasion and metastasis. Cancer Res 9-1-2004;64(17):6225-6232. View abstract.

Etogo-Asse, F., Boemer, F., Sempoux, C., and Geubel, A. Acute hepatitis with prolonged cholestasis and disappearance of interlobular bile ducts following tibolone and Hypericum perforatum (St. John's wort). Case of drug interaction? Acta Gastroenterol.Belg. 2008;71(1):36-38. View abstract.

Fava, M., Alpert, J., Nierenberg, A. A., Mischoulon, D., Otto, M. W., Zajecka, J., Murck, H., and Rosenbaum, J. F. A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder. J.Clin.Psychopharmacol. 2005;25(5):441-447. View abstract.

Feisst, C. and Werz, O. Suppression of receptor-mediated Ca2+ mobilization and functional leukocyte responses by hyperforin. Biochem Pharmacol 4-15-2004;67(8):1531-1539. View abstract.

Gastpar, M., Singer, A., and Zeller, K. Comparative efficacy and safety of a once-daily dosage of hypericum extract STW3-VI and citalopram in patients with moderate depression: a double-blind, randomised, multicentre, placebo-controlled study. Pharmacopsychiatry 2006;39(2):66-75. View abstract.

Ghazanfarpour, M., Kaviani, M., Asadi, N., Ghaffarpasand, F., Ziyadlou, S., Tabatabaee, H. R., and Dehghankhalili, M. Hypericum perforatum for the treatment of premenstrual syndrome. Int.J.Gynaecol.Obstet. 2011;113(1):84-85. View abstract.

Gobbi, M., Moia, M., Funicello, M., Riva, A., Morazzoni, P., and Mennini, T. In vitro effects of the dicyclohexylammonium salt of hyperforin on interleukin-6 release in different experimental models. Planta Med 2004;70(7):680-682. View abstract.

Greeson, J. M., Sanford, B., and Monti, D. A. St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology (Berl) 2001;153(4):402-414. View abstract.

Guzelcan, Y., Scholte, W. F., Assies, J., and Becker, H. E. [Mania during the use of a combination preparation with St. John's wort (Hypericum perforatum)]. Ned.Tijdschr.Geneeskd. 10-6-2001;145(40):1943-1945. View abstract.

Harrer, G., Hubner, W. D., and Podzuweit, H. Effectiveness and tolerance of the hypericum extract LI 160 compared to maprotiline: a multicenter double-blind study. J.Geriatr.Psychiatry Neurol. 1994;7 Suppl 1:S24-S28. View abstract.

Hicks, S. M., Walker, A. F., Gallagher, J., Middleton, R. W., and Wright, J. The significance of "nonsignificance" in randomized controlled studies: a discussion inspired by a double-blinded study on St. John's wort (Hypericum perforatum L.) for premenstrual symptoms. J.Altern.Complement Med. 2004;10(6):925-932. View abstract.

Hostanska, K., Reichling, J., Bommer, S., Weber, M., and Saller, R. Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. Eur.J Pharm Biopharm. 2003;56(1):121-132. View abstract.

Hudson, J. B., Graham, E. A., and Towers, G. H. Antiviral assays on phytochemicals: the influence of reaction parameters. Planta Med. 1994;60(4):329-332. View abstract.

Hudson, J. B., Lopez-Bazzocchi, I., and Towers, G. H. Antiviral activities of hypericin. Antiviral Res 1991;15(2):101-112. View abstract.

Hunt, E. J., Lester, C. E., Lester, E. A., and Tackett, R. L. Effect of St. John's wort on free radical production. Life Sci 6-1-2001;69(2):181-190. View abstract.

Izzo, A. A. and Ernst, E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs 2009;69(13):1777-1798. View abstract.

Kalb, R., Trautmann-Sponsel, R. D., and Kieser, M. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial. Pharmacopsychiatry 2001;34(3):96-103. View abstract.

Kasper, S. Treatment of seasonal affective disorder (SAD) with hypericum extract. Pharmacopsychiatry 1997;30 Suppl 2:89-93. View abstract.

Kasper, S., Gastpar, M., Moller, H. J., Muller, W. E., Volz, H. P., Dienel, A., and Kieser, M. Better tolerability of St. John's wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression. Int.Clin.Psychopharmacol. 2010;25(4):204-213. View abstract.

Kasper, S., Volz, H. P., Moller, H. J., Dienel, A., and Kieser, M. Continuation and long-term maintenance treatment with Hypericum extract WS 5570 after recovery from an acute episode of moderate depression--a double-blind, randomized, placebo controlled long-term trial. Eur.Neuropsychopharmacol. 2008;18(11):803-813. View abstract.

Kerb, R., Brockmoller, J., Staffeldt, B., Ploch, M., and Roots, I. Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin. Antimicrob.Agents Chemother. 1996;40(9):2087-2093. View abstract.

Knuppel, L. and Linde, K. Adverse effects of St. John's Wort: a systematic review. J Clin.Psychiatry 2004;65(11):1470-1479. View abstract.

Kobak, K. A., Taylor, L. V., Warner, G., and Futterer, R. St. John's wort versus placebo in social phobia: results from a placebo-controlled pilot study. J.Clin Psychopharmacol. 2005;25(1):51-58. View abstract.

Kobak, K. A., Taylor, L., Futterer, R., and Warner, G. St. John's wort in generalized anxiety disorder: three more case reports. J Clin Psychopharmacol. 2003;23(5):531-532. View abstract.

Laird RD and Webb M. Psychotic episode during use of St John's wort. J Herbal Pharmacother 2001;1(2):81-87.

Lavie, G., Valentine, F., Levin, B., Mazur, Y., Gallo, G., Lavie, D., Weiner, D., and Meruelo, D. Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. Proc Natl.Acad.Sci U.S.A 1989;86(15):5963-5967. View abstract.

Lecrubier Y. Clinical significance of hyperforin for the efficacy of Hypericum extracts on depressive disorders of different severities. Eur Neuropsychopharmacol 2001;11:105-106.

Lecrubier, Y., Clerc, G., Didi, R., and Kieser, M. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial. Am J Psychiatry 2002;159(8):1361-1366. View abstract.

Leuschner G. Preclinical toxicology profile of Hypericum extract LI 160. Phytomedicine 1996;supplement 1:104.

Linde, K., Berner, M. M., and Kriston, L. St John's wort for major depression. Cochrane.Database.Syst.Rev. 2008;(4):CD000448. View abstract.

Linde, K., Berner, M., Egger, M., and Mulrow, C. St John's wort for depression: meta-analysis of randomised controlled trials. Br.J Psychiatry 2005;186:99-107. View abstract.

Lopez-Bazzocchi, I., Hudson, J. B., and Towers, G. H. Antiviral activity of the photoactive plant pigment hypericin. Photochem.Photobiol. 1991;54(1):95-98. View abstract.

Martinez, B., Kasper, S., Ruhrmann, S., and Moller, H. J. Hypericum in the treatment of seasonal affective disorders. J Geriatr.Psychiatry Neurol. 1994;7 Suppl 1:S29-S33. View abstract.

Melzer, J., Brignoli, R., Keck, M. E., and Saller, R. A hypericum extract in the treatment of depressive symptoms in outpatients: an open study. Forsch.Komplementmed. 2010;17(1):7-14. View abstract.

Meruelo, D., Lavie, G., and Lavie, D. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Proc.Natl.Acad.Sci U.S.A 1988;85(14):5230-5234. View abstract.

Müller WE, Rolli, M., Schafer, C., and Hafner, U. Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiatry 1997;30 Suppl 2:102-107. View abstract.

Muller, T., Mannel, M., Murck, H., and Rahlfs, V. W. Treatment of somatoform disorders with St. John's wort: a randomized, double-blind and placebo-controlled trial. Psychosom.Med. 2004;66(4):538-547. View abstract.

Nahrstedt, A. and Butterweck, V. Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry 1997;30 Suppl 2:129-134. View abstract.

Najafizadeh, P., Hashemian, F., Mansouri, P., Farshi, S., Surmaghi, M. S., and Chalangari, R. The evaluation of the clinical effect of topical St Johns wort (Hypericum perforatum L.) in plaque type psoriasis vulgaris: a pilot study. Australas.J.Dermatol. 2012;53(2):131-135. View abstract.

Nanayakkara, P. W., Meijboom, M., and Schouten, J. A. [Suicidal and aggressive thoughts as a result of taking a Hypericum preparation (St. John's wort)]. Ned.Tijdschr.Geneeskd. 6-11-2005;149(24):1347-1349. View abstract.

Nathan, P. J. Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology. J Psychopharmacol. 2001;15(1):47-54. View abstract.

Okpanyi, S. N., Lidzba, H., Scholl, B. C., and Miltenburger, H. G. [Genotoxicity of a standardized Hypericum extract]. Arzneimittelforschung. 1990;40(8):851-855. View abstract.


Source: http://www.webmd.com/vitamins-supplements/ingredientmono-329-ST%20JOHN%27S%20WORT.aspx?activeIngredientId=329&activeIngredientName=ST%20JOHN%27S%20WORT


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